2qvw

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[[Image:2qvw.jpg|left|200px]]
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{{Seed}}
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[[Image:2qvw.png|left|200px]]
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{{STRUCTURE_2qvw| PDB=2qvw | SCENE= }}
{{STRUCTURE_2qvw| PDB=2qvw | SCENE= }}
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'''Structure of Giardia Dicer refined against twinned data'''
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===Structure of Giardia Dicer refined against twinned data===
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==Overview==
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The crystal structure of the enzyme Dicer from Giardia intestinalis was solved to 3.3 A resolution by MAD using crystals belonging to space group P2(1)2(1)2 [Macrae et al. (2006), Science, 311, 195-198]. These crystals were derived from crystals that diffracted X-rays to 3.0 A resolution but were refractory to structure determination because they were twinned. It is shown here that the original Dicer crystals represent an unusual case of perfect pseudo-merohedral twinning of orthorhombic crystals. Before the twinning problem was overcome, it was possible to calculate a low-resolution electron-density map in space group P4(1) that was used to build a partial molecular model. Experimental phases were sufficient to identify heavy-atom sites that indicated space-group inconsistency, leading to identification of the true space group. This information guided the search for different crystallization conditions that yielded untwinned crystals and ultimately a fully interpretable electron-density map.
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The line below this paragraph, {{ABSTRACT_PUBMED_17704568}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17704568 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17704568}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Rnai,pseudo-merohedral twin]]
[[Category: Rnai,pseudo-merohedral twin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:47:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:54:25 2008''

Revision as of 12:54, 28 July 2008

Image:2qvw.png

Template:STRUCTURE 2qvw

Structure of Giardia Dicer refined against twinned data

Template:ABSTRACT PUBMED 17704568

About this Structure

2QVW is a Single protein structure of sequence from Giardia intestinalis. Full crystallographic information is available from OCA.

Reference

An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer., MacRae IJ, Doudna JA, Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):993-9. Epub 2007, Aug 17. PMID:17704568

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