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2qxw

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[[Image:2qxw.jpg|left|200px]]
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{{STRUCTURE_2qxw| PDB=2qxw | SCENE= }}
{{STRUCTURE_2qxw| PDB=2qxw | SCENE= }}
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'''Perdeuterated alr2 in complex with idd594'''
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===Perdeuterated alr2 in complex with idd594===
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==Overview==
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We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 A, 100K; 0.80 A, 15K; 1.75 A, 293K), neutron Laue data (2.2 A, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and mobility of the hydrogen bond network that defines the properties of the catalytic engine, explaining how this promiscuous enzyme overcomes the simultaneous requirements of efficiency and promiscuity offering a general mechanistic view for this class of enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 18250329 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18250329}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:52:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:09 2008''

Revision as of 11:20, 29 July 2008

Image:2qxw.png

Template:STRUCTURE 2qxw

Perdeuterated alr2 in complex with idd594

Template:ABSTRACT PUBMED 18250329

About this Structure

2QXW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase., Blakeley MP, Ruiz F, Cachau R, Hazemann I, Meilleur F, Mitschler A, Ginell S, Afonine P, Ventura ON, Cousido-Siah A, Haertlein M, Joachimiak A, Myles D, Podjarny A, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1844-8. Epub 2008 Feb 4. PMID:18250329

Page seeded by OCA on Tue Jul 29 14:20:09 2008

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