2r15

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{{STRUCTURE_2r15| PDB=2r15 | SCENE= }}
{{STRUCTURE_2r15| PDB=2r15 | SCENE= }}
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'''Crystal structure of the myomesin domains 12 and 13'''
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===Crystal structure of the myomesin domains 12 and 13===
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==Overview==
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Sarcomeric filament proteins display extraordinary properties in terms of protein length and mechanical elasticity, requiring specific anchoring and assembly mechanisms. To establish the molecular basis of terminal filament assembly, we have selected the sarcomeric M-band protein myomesin as a prototypic filament model. The crystal structure of the myomesin C-terminus, comprising a tandem array of two immunoglobulin (Ig) domains My12 and My13, reveals a dimeric end-to-end filament of 14.3 nm length. Although the two domains share the same fold, an unexpected rearrangement of one beta-strand reveals how they are evolved into unrelated functions, terminal filament assembly (My13) and filament propagation (My12). The two domains are connected by a six-turn alpha-helix, of which two turns are void of any interactions with other protein parts. Thus, the overall structure of the assembled myomesin C-terminus resembles a three-body beads-on-the-string model with potentially elastic properties. We predict that the found My12-helix-My13 domain topology may provide a structural template for the filament architecture of the entire C-terminal Ig domain array My9-My13 of myomesin.
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(as it appears on PubMed at http://www.pubmed.gov), where 18059477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18059477}}
==About this Structure==
==About this Structure==
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[[Category: Sarcomeric protein]]
[[Category: Sarcomeric protein]]
[[Category: Thick filament]]
[[Category: Thick filament]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:03:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:29:31 2008''

Revision as of 23:29, 27 July 2008

Image:2r15.png

Template:STRUCTURE 2r15

Crystal structure of the myomesin domains 12 and 13

Template:ABSTRACT PUBMED 18059477

About this Structure

2R15 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin., Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M, EMBO J. 2008 Jan 9;27(1):253-64. Epub 2007 Dec 6. PMID:18059477

Page seeded by OCA on Mon Jul 28 02:29:31 2008

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