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2r2w

From Proteopedia

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[[Image:2r2w.jpg|left|200px]]
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{{STRUCTURE_2r2w| PDB=2r2w | SCENE= }}
{{STRUCTURE_2r2w| PDB=2r2w | SCENE= }}
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'''Urokinase plasminogen activator B-chain-GPPE complex'''
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===Urokinase plasminogen activator B-chain-GPPE complex===
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==Overview==
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Crystal structure of 2-(4-guanidynephenyl)-1-phenyl-ethanone (GPPE) in two different environments was determined in order to compare the binding geometry of these compound to a simple picrate anion and to protein, urokinase-type plasminogen activator (uPA), which may be treated as a target for anti-cancer drugs. It was shown that the conformation and the hydrogen-bonding formation by GPPE molecule are similar in both environments, but several important differences were discovered and described.
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(as it appears on PubMed at http://www.pubmed.gov), where 17905583 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17905583}}
==Disease==
==Disease==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Urokinase]]
[[Category: Urokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:08:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:54:32 2008''

Revision as of 08:54, 29 July 2008

Image:2r2w.png

Template:STRUCTURE 2r2w

Contents

Urokinase plasminogen activator B-chain-GPPE complex

Template:ABSTRACT PUBMED 17905583

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

2R2W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator., Zeslawska E, Sturzebecher J, Oleksyn BJ, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6212-5. Epub 2007 Sep 8. PMID:17905583

Page seeded by OCA on Tue Jul 29 11:54:32 2008

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