2r6f

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{{STRUCTURE_2r6f| PDB=2r6f | SCENE= }}
{{STRUCTURE_2r6f| PDB=2r6f | SCENE= }}
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'''Crystal Structure of Bacillus stearothermophilus UvrA'''
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===Crystal Structure of Bacillus stearothermophilus UvrA===
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==Overview==
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The nucleotide excision repair pathway corrects many structurally unrelated DNA lesions. Damage recognition in bacteria is performed by UvrA, a member of the ABC ATPase superfamily whose functional form is a dimer with four nucleotide-binding domains (NBDs), two per protomer. In the 3.2 A structure of UvrA from Bacillus stearothermophilus, we observe that the nucleotide-binding sites are formed in an intramolecular fashion and are not at the dimer interface as is typically found in other ABC ATPases. UvrA also harbors two unique domains; we show that one of these is required for interaction with UvrB, its partner in lesion recognition. In addition, UvrA contains three zinc modules, the number and ligand sphere of which differ from previously published models. Structural analysis, biochemical experiments, surface electrostatics, and sequence conservation form the basis for models of ATP-modulated dimerization, UvrA-UvrB interaction, and DNA binding during the search for lesions.
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{{ABSTRACT_PUBMED_18158267}}
==About this Structure==
==About this Structure==
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[[Category: Uvra]]
[[Category: Uvra]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:25:05 2008''

Revision as of 01:25, 28 July 2008

Image:2r6f.png

Template:STRUCTURE 2r6f

Crystal Structure of Bacillus stearothermophilus UvrA

Template:ABSTRACT PUBMED 18158267

About this Structure

2R6F is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding., Pakotiprapha D, Inuzuka Y, Bowman BR, Moolenaar GF, Goosen N, Jeruzalmi D, Verdine GL, Mol Cell. 2008 Jan 18;29(1):122-33. Epub 2007 Dec 27. PMID:18158267

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