2r6n

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[[Image:2r6n.jpg|left|200px]]
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{{STRUCTURE_2r6n| PDB=2r6n | SCENE= }}
{{STRUCTURE_2r6n| PDB=2r6n | SCENE= }}
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'''Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K'''
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===Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K===
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==Overview==
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Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.
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The line below this paragraph, {{ABSTRACT_PUBMED_17911019}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17911019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17911019}}
==About this Structure==
==About this Structure==
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[[Category: Thiol protease]]
[[Category: Thiol protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:20:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:31:09 2008''

Revision as of 17:31, 28 July 2008

Template:STRUCTURE 2r6n

Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K

Template:ABSTRACT PUBMED 17911019

About this Structure

2R6N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel scaffold for cathepsin K inhibitors., Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. Epub 2007 Sep 15. PMID:17911019

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