2r83

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{{STRUCTURE_2r83| PDB=2r83 | SCENE= }}
{{STRUCTURE_2r83| PDB=2r83 | SCENE= }}
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'''Crystal structure analysis of human synaptotagmin 1 C2A-C2B'''
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===Crystal structure analysis of human synaptotagmin 1 C2A-C2B===
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==Overview==
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Release of neurotransmitter from synaptic vesicles requires the Ca2+/phospholipid-binding protein synaptotagmin 1. There is considerable evidence that cooperation between the tandem C2 domains of synaptotagmin is a requirement of regulated exocytosis; however, high-resolution structural evidence for this interaction has been lacking. The 2.7 A crystal structure of the cytosolic domains of human synaptotagmin 1 in the absence of Ca2+ reveals a novel closed conformation of the protein. The shared interface between C2A and C2B is stabilized by a network of interactions between residues on the C-terminal alpha-helix of the C2B domain and residues on loops 1-3 of the Ca2+-binding region of C2A. These interactions alter the overall shape of the Ca2+-binding pocket of C2A, but not that of C2B. Thus, synaptotagmin 1 C2A-C2B may utilize a novel regulatory mechanism whereby one C2 domain could regulate the other until an appropriate triggering event decouples them.
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{{ABSTRACT_PUBMED_17956130}}
==About this Structure==
==About this Structure==
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[[Category: Synapse]]
[[Category: Synapse]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:24:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:30:26 2008''

Revision as of 04:30, 29 July 2008

Image:2r83.png

Template:STRUCTURE 2r83

Crystal structure analysis of human synaptotagmin 1 C2A-C2B

Template:ABSTRACT PUBMED 17956130

About this Structure

2R83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association., Fuson KL, Montes M, Robert JJ, Sutton RB, Biochemistry. 2007 Nov 13;46(45):13041-8. Epub 2007 Oct 23. PMID:17956130

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