2r9r

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[[Image:2r9r.jpg|left|200px]]
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{{Seed}}
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[[Image:2r9r.png|left|200px]]
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{{STRUCTURE_2r9r| PDB=2r9r | SCENE= }}
{{STRUCTURE_2r9r| PDB=2r9r | SCENE= }}
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'''Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit'''
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===Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit===
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==Overview==
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Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and muscle. This type of channel is gated directly by membrane voltage through protein domains known as voltage sensors, which are molecular voltmeters that read the membrane voltage and regulate the pore. Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle has been transferred from Kv2.1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2.4 angstrom resolution reveals the pore and voltage sensors embedded in a membrane-like arrangement of lipid molecules. The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating.
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The line below this paragraph, {{ABSTRACT_PUBMED_18004376}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18004376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18004376}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18004376 18004376]
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18004376 18004376]
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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel., Long SB, Campbell EB, Mackinnon R, Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16002581 16002581]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Voltage sensor]]
[[Category: Voltage sensor]]
[[Category: Voltage-gated channel]]
[[Category: Voltage-gated channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:29:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:52:15 2008''

Revision as of 02:52, 29 July 2008

Image:2r9r.png

Template:STRUCTURE 2r9r

Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit

Template:ABSTRACT PUBMED 18004376

About this Structure

2R9R is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel., Long SB, Campbell EB, Mackinnon R, Science. 2005 Aug 5;309(5736):897-903. Epub 2005 Jul 7. PMID:16002581

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