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2r9z

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{{STRUCTURE_2r9z| PDB=2r9z | SCENE= }}
{{STRUCTURE_2r9z| PDB=2r9z | SCENE= }}
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'''Glutathione amide reductase from Chromatium gracile'''
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===Glutathione amide reductase from Chromatium gracile===
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==Overview==
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Glutathione reductase (GR) plays a vital role in maintaining the antioxidant levels of the cytoplasm by catalyzing the reduction of glutathione disulfide to reduced glutathione, thereby using NADPH and flavin adenine dinucleotide as cofactors. Chromatiaceae have evolved an unusual homolog that prefers both a modified substrate (glutathione amide disulfide [GASSAG]) and a different cofactor (NADH). Herein, we present the crystal structure of the Chromatium gracile glutathione amide reductase (GAR) both alone and in complex with NAD(+). An altered charge distribution in the GASSAG binding pocket explains the difference in substrate specificity. The NADH binding pocket of GAR differs from that of wild-type GR as well as that of a low active GR that was engineered to mimic NADH binding. Based on the GAR structure, we propose two attractive rationales for producing an efficient GR enzyme with NADH specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 17977556 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17977556}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Substrate specificity]]
[[Category: Substrate specificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:30:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:42:10 2008''

Revision as of 16:42, 27 July 2008

Image:2r9z.png

Template:STRUCTURE 2r9z

Glutathione amide reductase from Chromatium gracile

Template:ABSTRACT PUBMED 17977556

About this Structure

2R9Z is a Single protein structure of sequence from Marichromatium gracile. Full crystallographic information is available from OCA.

Reference

Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase., Van Petegem F, De Vos D, Savvides S, Vergauwen B, Van Beeumen J, J Mol Biol. 2007 Dec 7;374(4):883-9. Epub 2007 Sep 29. PMID:17977556

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