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2rck

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[[Image:2rck.jpg|left|200px]]
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{{STRUCTURE_2rck| PDB=2rck | SCENE= }}
{{STRUCTURE_2rck| PDB=2rck | SCENE= }}
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'''Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph'''
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===Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph===
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==Overview==
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Low molecular weight juvenile hormone binding proteins (JHBPs) are specific carriers of juvenile hormone (JH) in the hemolymph of butterflies and moths. As hormonal signal transmitters, these proteins exert a profound effect on insect development. The crystal structure of JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a highly curved antiparallel beta-sheet. JHBP structurally resembles the folding pattern found in tandem repeats in some mammalian lipid-binding proteins, with similar organization of one cavity and a disulfide bond between the long helix and the beta-sheet. JHBP reveals, therefore, an archetypal fold used by nature for hydrophobic ligand binding. The JHBP molecule possesses two hydrophobic cavities. Several lines of experimental evidence conclusively indicate that JHBP binds JH in only one cavity, close to the N- and C-termini, and that this binding induces a structural change. The second cavity, located at the opposite end of the molecule, could bind another ligand.
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(as it appears on PubMed at http://www.pubmed.gov), where 18291417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18291417}}
==About this Structure==
==About this Structure==
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[[Category: Jhbp-fold]]
[[Category: Jhbp-fold]]
[[Category: Juvenile hormone]]
[[Category: Juvenile hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:38:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:50:27 2008''

Revision as of 12:50, 28 July 2008

Image:2rck.png

Template:STRUCTURE 2rck

Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph

Template:ABSTRACT PUBMED 18291417

About this Structure

2RCK is a Single protein structure of sequence from Galleria mellonella. Full crystallographic information is available from OCA.

Reference

Insect Juvenile Hormone Binding Protein Shows Ancestral Fold Present in Human Lipid-Binding Proteins., Kolodziejczyk R, Bujacz G, Jakob M, Ozyhar A, Jaskolski M, Kochman M, J Mol Biol. 2008 Jan 16;. PMID:18291417

Page seeded by OCA on Mon Jul 28 15:50:27 2008

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