2rip

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2rip.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2rip.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2rip| PDB=2rip | SCENE= }}
{{STRUCTURE_2rip| PDB=2rip | SCENE= }}
-
'''Structure of DPPIV in complex with an inhibitor'''
+
===Structure of DPPIV in complex with an inhibitor===
-
==Overview==
+
<!--
-
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single digit DPP-IV inhibitor 53 exhibited a preferred PK/PD profile in preclinical animal models and was selected for additional profiling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17977724}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17977724 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17977724}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:58:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:04:27 2008''

Revision as of 01:04, 29 July 2008

Image:2rip.png

Template:STRUCTURE 2rip

Structure of DPPIV in complex with an inhibitor

Template:ABSTRACT PUBMED 17977724

About this Structure

2RIP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors., Corbett JW, Dirico K, Song W, Boscoe BP, Doran SD, Boyer D, Qiu X, Ammirati M, Vanvolkenburg MA, McPherson RK, Parker JC, Cox ED, Bioorg Med Chem Lett. 2007 Dec 15;17(24):6707-13. Epub 2007 Oct 22. PMID:17977724

Page seeded by OCA on Tue Jul 29 04:04:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rip"
Personal tools