This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2rji

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2rji.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2rji.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2rji| PDB=2rji | SCENE= }}
{{STRUCTURE_2rji| PDB=2rji | SCENE= }}
-
'''Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface'''
+
===Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface===
-
==Overview==
+
<!--
-
The malaria parasite proliferates in the bloodstream of its vertebrate host by invading and replicating within erythrocytes. To achieve successful invasion, a number of discrete and essential events need to take place at the parasite-host cell interface. Erythrocyte-binding antigen 175 (EBA-175) is a member of a family of Plasmodium falciparum erythrocyte-binding proteins involved in the formation of a tight junction, a necessary step in invasion. Here we present the crystal structure of EBA-175 region VI (rVI), a cysteine-rich domain that is highly conserved within the protein family and is essential for EBA-175 trafficking. The structure was solved by selenomethionine single-wavelength anomalous dispersion at 1.8 A resolution. It reveals a homodimer, containing in each subunit a compact five-alpha-helix core that is stabilized by four conserved disulfide bridges. rVI adopts a novel fold that is likely conserved across the protein family, indicating a conserved function. It shows no similarity to the Duffy-binding-like domains of EBA-175 involved in erythrocyte binding, indicating a distinct role. Remarkably, rVI possesses structural features related to the KIX-binding domain of the coactivator CREB-binding protein, supporting the binding and trafficking roles that have been ascribed to it and providing a rational basis for further experimental investigation of its function.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18036613}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18036613 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18036613}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Region vi]]
[[Category: Region vi]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:02:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:05:13 2008''

Revision as of 13:05, 27 July 2008

Image:2rji.png

Template:STRUCTURE 2rji

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface

Template:ABSTRACT PUBMED 18036613

About this Structure

2RJI is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface., Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ, J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1. PMID:18036613

Page seeded by OCA on Sun Jul 27 16:05:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rji"
Personal tools