2rji

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{{STRUCTURE_2rji| PDB=2rji | SCENE= }}
{{STRUCTURE_2rji| PDB=2rji | SCENE= }}
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'''Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface'''
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===Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface===
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==Overview==
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The malaria parasite proliferates in the bloodstream of its vertebrate host by invading and replicating within erythrocytes. To achieve successful invasion, a number of discrete and essential events need to take place at the parasite-host cell interface. Erythrocyte-binding antigen 175 (EBA-175) is a member of a family of Plasmodium falciparum erythrocyte-binding proteins involved in the formation of a tight junction, a necessary step in invasion. Here we present the crystal structure of EBA-175 region VI (rVI), a cysteine-rich domain that is highly conserved within the protein family and is essential for EBA-175 trafficking. The structure was solved by selenomethionine single-wavelength anomalous dispersion at 1.8 A resolution. It reveals a homodimer, containing in each subunit a compact five-alpha-helix core that is stabilized by four conserved disulfide bridges. rVI adopts a novel fold that is likely conserved across the protein family, indicating a conserved function. It shows no similarity to the Duffy-binding-like domains of EBA-175 involved in erythrocyte binding, indicating a distinct role. Remarkably, rVI possesses structural features related to the KIX-binding domain of the coactivator CREB-binding protein, supporting the binding and trafficking roles that have been ascribed to it and providing a rational basis for further experimental investigation of its function.
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{{ABSTRACT_PUBMED_18036613}}
==About this Structure==
==About this Structure==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Region vi]]
[[Category: Region vi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:02:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:05:13 2008''

Revision as of 13:05, 27 July 2008

Image:2rji.png

Template:STRUCTURE 2rji

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface

Template:ABSTRACT PUBMED 18036613

About this Structure

2RJI is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface., Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ, J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1. PMID:18036613

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