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2sas

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{{STRUCTURE_2sas| PDB=2sas | SCENE= }}
{{STRUCTURE_2sas| PDB=2sas | SCENE= }}
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'''STRUCTURE OF A SARCOPLASMIC CALCIUM-BINDING PROTEIN FROM AMPHIOXUS REFINED AT 2.4 ANGSTROMS RESOLUTION'''
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===STRUCTURE OF A SARCOPLASMIC CALCIUM-BINDING PROTEIN FROM AMPHIOXUS REFINED AT 2.4 ANGSTROMS RESOLUTION===
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==Overview==
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The three-dimensional structure of a sarcoplasmic Ca(2+)-binding protein from the protochordate amphioxus has been determined at 2.4 A resolution using multiple-isomorphous-replacement techniques. The refined model includes all 185 residues, three calcium ions, and one water molecule. The final crystallographic R-factor is 0.199. Bond lengths and bond angles in the molecules have root-mean-square deviations from ideal values of 0.015 A and 2.8 degrees, respectively. The overall structure is highly compact and globular with a predominantly hydrophobic core, unlike the extended dumbbell-shaped structures of calmodulin or troponin C. There are four distinct domains with the typical helix-loop-helix Ca(2+)-binding motif (EF hand). The conformation of the pair of EF hands in the N-terminal half of the protein is unusual due to the presence of an aspartate residue in the twelfth position of the first Ca(2+)-binding loop, rather than the usual glutamate. The C-terminal half of the molecule contains one Ca(2+)-binding domain with a novel helix-loop-helix conformation and one Ca(2+)-binding domain that is no longer functional because of amino acid changes. The overall structure is quite similar to a sarcoplasmic Ca(2+)-binding protein from sandworm, although there is only about 12% amino acid sequence identity between them. The similarity of the structures of these two proteins suggests that all sarcoplasmic Ca(2+)-binding proteins will have the same general conformation, even though there is very little conservation of primary structure among the proteins from various species.
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{{ABSTRACT_PUBMED_8429557}}
==About this Structure==
==About this Structure==
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[[Category: Cox, J A.]]
[[Category: Cox, J A.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:45:34 2008''

Revision as of 05:45, 28 July 2008

Image:2sas.png

Template:STRUCTURE 2sas

STRUCTURE OF A SARCOPLASMIC CALCIUM-BINDING PROTEIN FROM AMPHIOXUS REFINED AT 2.4 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8429557

About this Structure

2SAS is a Single protein structure of sequence from Branchiostoma lanceolatum. Full crystallographic information is available from OCA.

Reference

Structure of a sarcoplasmic calcium-binding protein from amphioxus refined at 2.4 A resolution., Cook WJ, Jeffrey LC, Cox JA, Vijay-Kumar S, J Mol Biol. 1993 Jan 20;229(2):461-71. PMID:8429557

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