2sem

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2sem.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2sem.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2sem| PDB=2sem | SCENE= }}
{{STRUCTURE_2sem| PDB=2sem | SCENE= }}
-
'''SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR'''
+
===SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR===
-
==Overview==
+
<!--
-
Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich sequences. However, instead of recognizing critical prolines on the basis of side chain shape or rigidity, these domains broadly accepted amide N-substituted residues. Proline is apparently specifically selected in vivo, despite low complementarity, because it is the only endogenous N-substituted amino acid. This discriminatory mechanism explains how these domains achieve specific but low-affinity recognition, a property that is necessary for transient signaling interactions. The mechanism can be exploited: screening a series of ligands in which key prolines were replaced by nonnatural N-substituted residues yielded a ligand that selectively bound the Grb2 SH3 domain with 100 times greater affinity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9851931}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9851931 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9851931}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:18:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:21:24 2008''

Revision as of 08:21, 28 July 2008

Image:2sem.png

Template:STRUCTURE 2sem

SEM5 SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR

Template:ABSTRACT PUBMED 9851931

About this Structure

2SEM is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors., Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA, Science. 1998 Dec 11;282(5396):2088-92. PMID:9851931

Page seeded by OCA on Mon Jul 28 11:21:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2sem"
Personal tools