2tcl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2tcl.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2tcl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2tcl| PDB=2tcl | SCENE= }}
{{STRUCTURE_2tcl| PDB=2tcl | SCENE= }}
-
'''STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR'''
+
===STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR===
-
==Overview==
+
<!--
-
In rheumatoid and osteoarthritis, degradation of articular cartilage is mediated by the matrix metalloproteinases collagenase, stromelysin and gelatinase. The key event in this process is the cleavage of triple helical collagen by collagenase. We have determined the crystal structure of the catalytic domain of human recombinant fibroblast collagenase complexed with a synthetic inhibitor at 2.2 A resolution. The protein fold is similar to the amino termini of the zinc endopeptidases astacin thermolysin and elastase despite a lack of primary sequence homology. The conformation of the bound inhibitor provides a molecular basis for the design of inhibitors of collagenase and other matrix metalloproteinases. Such inhibitors should be useful in the treatment of a variety of diseases including arthritis and cancer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7656013}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7656013 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7656013}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Borkakoti, N.]]
[[Category: Borkakoti, N.]]
[[Category: Winkler, F K.]]
[[Category: Winkler, F K.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:22:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:52:21 2008''

Revision as of 21:52, 28 July 2008

Image:2tcl.png

Template:STRUCTURE 2tcl

STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR

Template:ABSTRACT PUBMED 7656013

About this Structure

2TCL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor., Borkakoti N, Winkler FK, Williams DH, D'Arcy A, Broadhurst MJ, Brown PA, Johnson WH, Murray EJ, Nat Struct Biol. 1994 Feb;1(2):106-10. PMID:7656013

Page seeded by OCA on Tue Jul 29 00:52:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2tcl"
Personal tools