2trc

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[[Image:2trc.gif|left|200px]]
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{{STRUCTURE_2trc| PDB=2trc | SCENE= }}
{{STRUCTURE_2trc| PDB=2trc | SCENE= }}
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'''PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX'''
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===PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX===
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==Overview==
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The crystal structure of transducin's betagamma subunits complexed with phosducin, which regulates Gtbetagamma activity, has been solved to 2.4 angstroms resolution. Phosducin has two domains that wrap around Gtbetagamma to form an extensive interface. The N-terminal domain binds loops on the "top" Gtbeta surface, overlapping the Gtalpha binding surface, explaining how phosducin blocks Gtbetagamma's interaction with Gtalpha. The C-terminal domain shows structural homology to thioredoxin and binds the outer strands of Gtbeta's seventh and first blades in a manner likely to disrupt Gtbetagamma's normal orientation relative to the membrane and receptor. Phosducin's Ser-73, which when phosphorylated inhibits phosducin's function, points away from Gtbetagamma, toward a large flexible loop. Thus phosphorylation is not likely to affect the interface directly, but rather indirectly through an induced conformational change.
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(as it appears on PubMed at http://www.pubmed.gov), where 8898209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8898209}}
==About this Structure==
==About this Structure==
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[[Category: Transducin]]
[[Category: Transducin]]
[[Category: Vision]]
[[Category: Vision]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:39:36 2008''

Revision as of 15:39, 28 July 2008

Image:2trc.png

Template:STRUCTURE 2trc

PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

Template:ABSTRACT PUBMED 8898209

About this Structure

2TRC is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin., Gaudet R, Bohm A, Sigler PB, Cell. 1996 Nov 1;87(3):577-88. PMID:8898209

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