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2uwq

From Proteopedia

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[[Image:2uwq.jpg|left|200px]]
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[[Image:2uwq.png|left|200px]]
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{{STRUCTURE_2uwq| PDB=2uwq | SCENE= }}
{{STRUCTURE_2uwq| PDB=2uwq | SCENE= }}
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'''SOLUTION STRUCTURE OF ASPP2 N-TERMINUS'''
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===SOLUTION STRUCTURE OF ASPP2 N-TERMINUS===
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==Overview==
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Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.
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The line below this paragraph, {{ABSTRACT_PUBMED_17594908}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17594908 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17594908}}
==About this Structure==
==About this Structure==
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2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
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2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
==Reference==
==Reference==
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[[Category: Sh3-domain]]
[[Category: Sh3-domain]]
[[Category: Ubiquitin-like]]
[[Category: Ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:41:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:22:07 2008''

Revision as of 13:22, 28 July 2008

Image:2uwq.png

Template:STRUCTURE 2uwq

SOLUTION STRUCTURE OF ASPP2 N-TERMINUS

Template:ABSTRACT PUBMED 17594908

About this Structure

2UWQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold., Tidow H, Andreeva A, Rutherford TJ, Fersht AR, J Mol Biol. 2007 Aug 24;371(4):948-58. Epub 2007 May 13. PMID:17594908

Page seeded by OCA on Mon Jul 28 16:22:07 2008

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