2uy1

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{{STRUCTURE_2uy1| PDB=2uy1 | SCENE= }}
{{STRUCTURE_2uy1| PDB=2uy1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF CSTF-77'''
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===CRYSTAL STRUCTURE OF CSTF-77===
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==Overview==
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The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defining two domains. The crystal structure reveals a tight homodimer exposing phylogenetically conserved areas for interaction with protein partners. Mapping experiments identify the C-terminal region of Rna14p, the yeast counterpart of CstF-77, as the docking domain for Rna15p, the yeast CstF-64 homologue.
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(as it appears on PubMed at http://www.pubmed.gov), where 17584787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17584787}}
==About this Structure==
==About this Structure==
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[[Category: Pinaud, N.]]
[[Category: Pinaud, N.]]
[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:36:20 2008''

Revision as of 03:36, 28 July 2008

Image:2uy1.png

Template:STRUCTURE 2uy1

CRYSTAL STRUCTURE OF CSTF-77

Template:ABSTRACT PUBMED 17584787

About this Structure

2UY1 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.

Reference

The structure of the CstF-77 homodimer provides insights into CstF assembly., Legrand P, Pinaud N, Minvielle-Sebastia L, Fribourg S, Nucleic Acids Res. 2007;35(13):4515-22. Epub 2007 Jun 21. PMID:17584787

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