2uzg

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[[Image:2uzg.jpg|left|200px]]
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{{STRUCTURE_2uzg| PDB=2uzg | SCENE= }}
{{STRUCTURE_2uzg| PDB=2uzg | SCENE= }}
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'''ZF-UBP DOMAIN OF VDU1'''
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===ZF-UBP DOMAIN OF VDU1===
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==Overview==
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USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
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(as it appears on PubMed at http://www.pubmed.gov), where 17766394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17766394}}
==About this Structure==
==About this Structure==
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2UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA].
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2UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA].
==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:52:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:56:54 2008''

Revision as of 14:56, 27 July 2008

Image:2uzg.png

Template:STRUCTURE 2uzg

ZF-UBP DOMAIN OF VDU1

Template:ABSTRACT PUBMED 17766394

About this Structure

2UZG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394

Page seeded by OCA on Sun Jul 27 17:56:54 2008

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