2uzy

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{{STRUCTURE_2uzy| PDB=2uzy | SCENE= }}
{{STRUCTURE_2uzy| PDB=2uzy | SCENE= }}
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'''STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASE MET IN COMPLEX WITH THE LISTERIA MONOCYTOGENES INVASION PROTEIN INLB: LOW RESOLUTION, CRYSTAL FORM II'''
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===STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASE MET IN COMPLEX WITH THE LISTERIA MONOCYTOGENES INVASION PROTEIN INLB: LOW RESOLUTION, CRYSTAL FORM II===
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==Overview==
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The tyrosine kinase Met, the product of the c-met proto-oncogene and the receptor for hepatocyte growth factor/scatter factor (HGF/SF), mediates signals critical for cell survival and migration. The human pathogen Listeria monocytogenes exploits Met signaling for invasion of host cells via its surface protein InlB. We present the crystal structure of the complex between a large fragment of the human Met ectodomain and the Met-binding domain of InlB. The concave face of the InlB leucine-rich repeat region interacts tightly with the first immunoglobulin-like domain of the Met stalk, a domain which does not bind HGF/SF. A second contact between InlB and the Met Sema domain locks the otherwise flexible receptor in a rigid, signaling competent conformation. Full Met activation requires the additional C-terminal domains of InlB which induce heparin-mediated receptor clustering and potent signaling. Thus, although it elicits a similar cellular response, InlB is not a structural mimic of HGF/SF.
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The line below this paragraph, {{ABSTRACT_PUBMED_17662939}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17662939 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17662939}}
==About this Structure==
==About this Structure==
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[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Virulence factor]]
[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:55:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:42:58 2008''

Revision as of 11:43, 28 July 2008

Image:2uzy.png

Template:STRUCTURE 2uzy

STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASE MET IN COMPLEX WITH THE LISTERIA MONOCYTOGENES INVASION PROTEIN INLB: LOW RESOLUTION, CRYSTAL FORM II

Template:ABSTRACT PUBMED 17662939

About this Structure

2UZY is a Protein complex structure of sequences from Homo sapiens and Listeria monocytogenes. Full crystallographic information is available from OCA.

Reference

Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB., Niemann HH, Jager V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW, Cell. 2007 Jul 27;130(2):235-46. PMID:17662939

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