2v0x

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[[Image:2v0x.gif|left|200px]]
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{{Seed}}
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[[Image:2v0x.png|left|200px]]
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{{STRUCTURE_2v0x| PDB=2v0x | SCENE= }}
{{STRUCTURE_2v0x| PDB=2v0x | SCENE= }}
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'''THE DIMERIZATION DOMAIN OF LAP2ALPHA'''
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===THE DIMERIZATION DOMAIN OF LAP2ALPHA===
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==Overview==
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Lamina-associated polypeptides (LAPs) are important components of the nuclear lamina, the dense network of filaments that supports the nuclear envelope and also extends into the nucleoplasm. The main protein constituents of the nuclear lamina are the constitutively expressed B-type lamins and the developmentally regulated A- and C-type lamins. LAP2alpha is the only non-membrane-associated member of the LAP family. It preferentially binds lamin A/C, has been implicated in cell-cycle regulation and chromatin organization, and has also been found to be a component of retroviral preintegration complexes. As an approach to understanding the role of LAP2alpha in cellular pathways, we have determined the crystal structure of the C-terminal domain of LAP2alpha, residues 459-693. The C-terminal domain is dimeric and possesses an extensive four-stranded, antiparallel coiled coil. The surface involved in binding lamin A/C is proposed based on results from alanine-scanning mutagenesis and a solid-phase overlay binding assay.
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(as it appears on PubMed at http://www.pubmed.gov), where 17562312 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17562312}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:59:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:13:08 2008''

Revision as of 17:13, 27 July 2008

Image:2v0x.png

Template:STRUCTURE 2v0x

THE DIMERIZATION DOMAIN OF LAP2ALPHA

Template:ABSTRACT PUBMED 17562312

About this Structure

2V0X is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina., Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman AB, Craigie R, Dyda F, Structure. 2007 Jun;15(6):643-53. PMID:17562312

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