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2v5z

From Proteopedia

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{{STRUCTURE_2v5z| PDB=2v5z | SCENE= }}
{{STRUCTURE_2v5z| PDB=2v5z | SCENE= }}
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'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE'''
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===STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE===
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==Overview==
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Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.
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(as it appears on PubMed at http://www.pubmed.gov), where 17915852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17915852}}
==About this Structure==
==About this Structure==
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[[Category: Safinamide]]
[[Category: Safinamide]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:14:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:58:47 2008''

Revision as of 18:58, 27 July 2008

Image:2v5z.png

Template:STRUCTURE 2v5z

STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR SAFINAMIDE

Template:ABSTRACT PUBMED 17915852

About this Structure

2V5Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:17915852

Page seeded by OCA on Sun Jul 27 21:58:47 2008

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