1a6s
From Proteopedia
(New page: 200px<br /><applet load="1a6s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a6s" /> '''M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOM...) |
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'''M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES'''<br /> | '''M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A biologically active construct of the retroviral M domain from the avian | + | A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization. |
==About this Structure== | ==About this Structure== | ||
| - | 1A6S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http:// | + | 1A6S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6S OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rous sarcoma virus]] | [[Category: Rous sarcoma virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cahill, S | + | [[Category: Cahill, S M.]] |
[[Category: Cowburn, D.]] | [[Category: Cowburn, D.]] | ||
[[Category: Fushman, D.]] | [[Category: Fushman, D.]] | ||
| - | [[Category: Mcdonnell, J | + | [[Category: Mcdonnell, J M.]] |
| - | [[Category: Nelle, T | + | [[Category: Nelle, T D.]] |
| - | [[Category: Resh, M | + | [[Category: Resh, M D.]] |
[[Category: Wills, J.]] | [[Category: Wills, J.]] | ||
| - | [[Category: Wilson, C | + | [[Category: Wilson, C B.]] |
[[Category: Wolven, A.]] | [[Category: Wolven, A.]] | ||
[[Category: Zhou, W.]] | [[Category: Zhou, W.]] | ||
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[[Category: virus structure]] | [[Category: virus structure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:28 2008'' |
Revision as of 09:41, 21 February 2008
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M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES
Overview
A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.
About this Structure
1A6S is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.
Reference
Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus., McDonnell JM, Fushman D, Cahill SM, Zhou W, Wolven A, Wilson CB, Nelle TD, Resh MD, Wills J, Cowburn D, J Mol Biol. 1998 Jun 19;279(4):921-8. PMID:9642071
Page seeded by OCA on Thu Feb 21 11:41:28 2008
