2v7c

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{{STRUCTURE_2v7c| PDB=2v7c | SCENE= }}
{{STRUCTURE_2v7c| PDB=2v7c | SCENE= }}
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'''CRYSTAL STRUCTURE OF REV-ERB BETA'''
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===CRYSTAL STRUCTURE OF REV-ERB BETA===
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==Overview==
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The Rev-erb family is an orphan nuclear receptor acting as a negative regulator of transcription. Rev-erbalpha and Rev-erbbeta are crucial components of the circadian clock and involved in various lipid homeostasis. They are unique nuclear receptors that lack the activation function 2 helix (AF2-helix) required for ligand-dependent activation by other members of nuclear receptors. Here, we report the crystal structure of Rev-erbbeta (NR1D2) in a dimeric arrangement. The putative ligand-binding pocket (LBP) of Rev-erbbeta is filled with bulky hydrophobic residues resulting in a residual cavity size that is too small to allow binding of any known ligand molecules. However, an alternative conformation of the putative LBP observed in another crystal form suggests the flexibility of this region. The kinked conformation of helix H11 allows helix H11 to bend toward helix H3 over the putative ligand binding pocket by filling and closing the cavity with its side-chains. In the absence of the AF2-helix and a cognate ligand, Rev-erbbeta appears to stabilize the hydrophobic cluster in the putative ligand binding pocket and provide a structural platform for co-repressor binding by adopting the unique geometry of helix H11, a suitable conformation for the constitutive repression activity.
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{{ABSTRACT_PUBMED_17870090}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:19:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:11:14 2008''

Revision as of 06:11, 29 July 2008

Image:2v7c.png

Template:STRUCTURE 2v7c

CRYSTAL STRUCTURE OF REV-ERB BETA

Template:ABSTRACT PUBMED 17870090

About this Structure

2V7C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta., Woo EJ, Jeong DG, Lim MY, Jun Kim S, Kim KJ, Yoon SM, Park BC, Eon Ryu S, J Mol Biol. 2007 Oct 26;373(3):735-44. Epub 2007 Aug 22. PMID:17870090

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