2v8k

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{{Seed}}
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{{STRUCTURE_2v8k| PDB=2v8k | SCENE= }}
{{STRUCTURE_2v8k| PDB=2v8k | SCENE= }}
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'''STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH TRIGALACTURONIC ACID'''
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===STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH TRIGALACTURONIC ACID===
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==Overview==
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The family 2 pectate lyase from Yersinia enterocolitica (YePL2A), solved to 1.5A, reveals it to be the first prokaryotic protein reported to display the rare (alpha/alpha)(7) barrel fold. In addition to its apo form, we have also determined the structure of a metal-bound form of YePL2A (to 2.0A) and a trigalacturonic acid-bound substrate complex (to 2.1A) Although its fold is rare, the catalytic center of YePL2A can be superimposed with structurally unrelated families, underlining the conserved catalytic amino acid architecture of the beta-elimination mechanism. In addition to its overall structure, YePL2A also has two other unique features: 1) it utilizes a metal atom other than calcium for catalysis, and 2) its Bronstead base is in an alternate conformation and directly interacts with the uronate group of the substrate.
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The line below this paragraph, {{ABSTRACT_PUBMED_17881361}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17881361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17881361}}
==About this Structure==
==About this Structure==
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[[Category: Pectin degradation]]
[[Category: Pectin degradation]]
[[Category: Periplasm]]
[[Category: Periplasm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:22:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:05:25 2008''

Revision as of 06:05, 29 July 2008

Image:2v8k.png

Template:STRUCTURE 2v8k

STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH TRIGALACTURONIC ACID

Template:ABSTRACT PUBMED 17881361

About this Structure

2V8K is a Single protein structure of sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA.

Reference

A family 2 pectate lyase displays a rare fold and transition metal-assisted beta-elimination., Abbott DW, Boraston AB, J Biol Chem. 2007 Nov 30;282(48):35328-36. Epub 2007 Sep 19. PMID:17881361

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