1a7h
From Proteopedia
(New page: 200px<br /><applet load="1a7h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7h, resolution 2.56Å" /> '''GAMMA S CRYSTALLIN C...) |
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| - | [[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size=" | + | [[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1a7h, resolution 2.56Å" /> | caption="1a7h, resolution 2.56Å" /> | ||
'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''<br /> | '''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The 2-domain gammaS-crystallin, a highly conserved early evolutionary | + | The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing. |
==About this Structure== | ==About this Structure== | ||
| - | 1A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http:// | + | 1A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Basak, A | + | [[Category: Basak, A K.]] |
[[Category: Slingsby, C.]] | [[Category: Slingsby, C.]] | ||
[[Category: eye lens protein]] | [[Category: eye lens protein]] | ||
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[[Category: multigene family]] | [[Category: multigene family]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:42 2008'' |
Revision as of 09:41, 21 February 2008
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GAMMA S CRYSTALLIN C-TERMINAL DOMAIN
Overview
The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
About this Structure
1A7H is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:9681865
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