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2v9u

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[[Image:2v9u.jpg|left|200px]]
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{{Seed}}
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[[Image:2v9u.png|left|200px]]
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{{STRUCTURE_2v9u| PDB=2v9u | SCENE= }}
{{STRUCTURE_2v9u| PDB=2v9u | SCENE= }}
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'''RIM DOMAIN OF MAIN PORIN FROM MYCOBACTERIA SMEGMATIS'''
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===RIM DOMAIN OF MAIN PORIN FROM MYCOBACTERIA SMEGMATIS===
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==Overview==
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The analysis of natural contact interfaces between protein subunits and between proteins has disclosed some general rules governing their association. We have applied these rules to produce a number of novel assemblies, demonstrating that a given protein can be engineered to form contacts at various points of its surface. Symmetry plays an important role because it defines the multiplicity of a designed contact and therefore the number of required mutations. Some of the proteins needed only a single side-chain alteration in order to associate to a higher-order complex. The mobility of the buried side chains has to be taken into account. Four assemblies have been structurally elucidated. Comparisons between the designed contacts and the results will provide useful guidelines for the development of future architectures.
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The line below this paragraph, {{ABSTRACT_PUBMED_18187656}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18187656 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18187656}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Designed protein-protein association., Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE, Science. 2008 Jan 11;319(5860):206-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18187656 18187656]
Designed protein-protein association., Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE, Science. 2008 Jan 11;319(5860):206-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18187656 18187656]
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The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14976314 14976314]
[[Category: Mycobacterium smegmatis]]
[[Category: Mycobacterium smegmatis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Porin]]
[[Category: Porin]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:27:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:08:38 2008''

Revision as of 03:08, 29 July 2008

Image:2v9u.png

Template:STRUCTURE 2v9u

RIM DOMAIN OF MAIN PORIN FROM MYCOBACTERIA SMEGMATIS

Template:ABSTRACT PUBMED 18187656

About this Structure

2V9U is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

Designed protein-protein association., Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE, Science. 2008 Jan 11;319(5860):206-9. PMID:18187656

The structure of a mycobacterial outer-membrane channel., Faller M, Niederweis M, Schulz GE, Science. 2004 Feb 20;303(5661):1189-92. PMID:14976314

Page seeded by OCA on Tue Jul 29 06:08:38 2008

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