2vdb

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{{STRUCTURE_2vdb| PDB=2vdb | SCENE= }}
{{STRUCTURE_2vdb| PDB=2vdb | SCENE= }}
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'''STRUCTURE OF HUMAN SERUM ALBUMIN WITH S-NAPROXEN AND THE GA MODULE'''
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===STRUCTURE OF HUMAN SERUM ALBUMIN WITH S-NAPROXEN AND THE GA MODULE===
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==Overview==
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The previously determined crystal structure of the bacterial albumin-binding GA module in complex with human serum albumin (HSA) suggested the possibility of utilizing the complex in the study of ligand binding to HSA. As a continuation of these studies, the crystal structure of the HSA-GA complex with the drug molecule naproxen and the fatty acid decanoate bound to HSA has been determined to a resolution of 2.5 A. In terms of drug binding, the structure suggests that the binding of decanoate to the albumin molecule may play a role in making the haemin site in subdomain IB of the albumin molecule available for the binding of naproxen. In addition, structure comparisons with solved structures of HSA and of the HSA-GA complex show that the GA module is capable of binding to different conformations of HSA. The HSA-GA complex therefore emerges as a possible platform for the crystallographic study of specific HSA-drug interactions and of the influence exerted by the presence of fatty acids.
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{{ABSTRACT_PUBMED_18259051}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:37:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:03:32 2008''

Revision as of 19:03, 28 July 2008

Image:2vdb.png

Template:STRUCTURE 2vdb

STRUCTURE OF HUMAN SERUM ALBUMIN WITH S-NAPROXEN AND THE GA MODULE

Template:ABSTRACT PUBMED 18259051

About this Structure

2VDB is a Protein complex structure of sequences from Finegoldia magna and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the binding of naproxen to human serum albumin in the presence of fatty acids and the GA module., Lejon S, Cramer JF, Nordberg P, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt, 2):64-9. Epub 2008 Jan 18. PMID:18259051

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