2vfj

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{{STRUCTURE_2vfj| PDB=2vfj | SCENE= }}
{{STRUCTURE_2vfj| PDB=2vfj | SCENE= }}
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'''STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN'''
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===STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN===
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==Overview==
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The NF-kappaB (nuclear factor kappaB) regulator A20 antagonises IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). In the present paper we describe the crystal structure of the N-terminal OTU (ovarian tumour) deubiquitinase domain of A20, which differs from other deubiquitinases but shares the minimal catalytic core with otubain-2. Analysis of conserved surface regions allows prediction of ubiquitin-binding sites for the proximal and distal ubiquitin molecules. Structural and biochemical analysis suggests a novel architecture of the catalytic triad, which might be present in a subset of OTU domains including Cezanne and TRABID (TRAF-binding domain). Biochemical analysis shows a preference of the isolated A20 OTU domain for Lys48-linked tetraubiquitin in vitro suggesting that additional specificity factors might be required for the physiological function of A20 in cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_17961127}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17961127 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17961127}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:42:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:59:50 2008''

Revision as of 21:59, 28 July 2008

Image:2vfj.png

Template:STRUCTURE 2vfj

STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN

Template:ABSTRACT PUBMED 17961127

About this Structure

2VFJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the A20 OTU domain and mechanistic insights into deubiquitination., Komander D, Barford D, Biochem J. 2008 Jan 1;409(1):77-85. PMID:17961127

Page seeded by OCA on Tue Jul 29 00:59:50 2008

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