2vit

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{{STRUCTURE_2vit| PDB=2vit | SCENE= }}
{{STRUCTURE_2vit| PDB=2vit | SCENE= }}
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'''INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY'''
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===INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY===
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==Overview==
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The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
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(as it appears on PubMed at http://www.pubmed.gov), where 9461077 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9461077}}
==About this Structure==
==About this Structure==
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[[Category: Wharton, S A.]]
[[Category: Wharton, S A.]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:53:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:26:17 2008''

Revision as of 01:26, 28 July 2008

Image:2vit.png

Template:STRUCTURE 2vit

INFLUENZA VIRUS HEMAGGLUTININ, MUTANT WITH THR 155 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY

Template:ABSTRACT PUBMED 9461077

About this Structure

2VIT is a Protein complex structure of sequences from Mus musculus and Unidentified influenza virus. Full crystallographic information is available from OCA.

Reference

Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077

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