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2wbc

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[[Image:2wbc.jpg|left|200px]]
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{{Seed}}
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[[Image:2wbc.png|left|200px]]
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{{STRUCTURE_2wbc| PDB=2wbc | SCENE= }}
{{STRUCTURE_2wbc| PDB=2wbc | SCENE= }}
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'''REFINED CRYSTAL STRUCTURE (2.3 ANGSTROM) OF A WINGED BEAN CHYMOTRYPSIN INHIBITOR AND LOCATION OF ITS SECOND REACTIVE SITE'''
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===REFINED CRYSTAL STRUCTURE (2.3 ANGSTROM) OF A WINGED BEAN CHYMOTRYPSIN INHIBITOR AND LOCATION OF ITS SECOND REACTIVE SITE===
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==Overview==
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The crystal structure of a double-headed alpha-chymotrypsin inhibitor, WCI, from winged bean seeds has now been refined at 2.3 A resolution to an R-factor of 18.7% for 9,897 reflections. The crystals belong to the hexagonal space group P6(1)22 with cell parameters a = b = 61.8 A and c = 212.8 A. The final model has a good stereochemistry and a root mean square deviation of 0.011 A and 1.14 degrees from ideality for bond length and bond angles, respectively. A total of 109 ordered solvent molecules were localized in the structure. This improved structure at 2.3 A led to an understanding of the mechanism of inhibition of the protein against alpha-chymotrypsin. An analysis of this higher resolution structure also helped us to predict the location of the second reactive site of the protein, about which no previous biochemical information was available. The inhibitor structure is spherical and has twelve anti-parallel beta-strands with connecting loops arranged in a characteristic beta-trefoil fold common to other homologous serine protease inhibitors in the Kunitz (STI) family as well as to some non homologous functionally unrelated proteins. A wide variation in the surface loop regions is seen in the latter ones.
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The line below this paragraph, {{ABSTRACT_PUBMED_10328267}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10328267 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10328267}}
==About this Structure==
==About this Structure==
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[[Category: Singh, M.]]
[[Category: Singh, M.]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:10:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:27:30 2008''

Revision as of 11:27, 28 July 2008

Image:2wbc.png

Template:STRUCTURE 2wbc

REFINED CRYSTAL STRUCTURE (2.3 ANGSTROM) OF A WINGED BEAN CHYMOTRYPSIN INHIBITOR AND LOCATION OF ITS SECOND REACTIVE SITE

Template:ABSTRACT PUBMED 10328267

About this Structure

2WBC is a Single protein structure of sequence from Psophocarpus tetragonolobus. Full crystallographic information is available from OCA.

Reference

Refined crystal structure (2.3 A) of a double-headed winged bean alpha-chymotrypsin inhibitor and location of its second reactive site., Dattagupta JK, Podder A, Chakrabarti C, Sen U, Mukhopadhyay D, Dutta SK, Singh M, Proteins. 1999 May 15;35(3):321-31. PMID:10328267

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