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2yxf

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{{STRUCTURE_2yxf| PDB=2yxf | SCENE= }}
{{STRUCTURE_2yxf| PDB=2yxf | SCENE= }}
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'''The high resolution crystal structure of beta2-microglobulin under physiological conditions'''
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===The high resolution crystal structure of beta2-microglobulin under physiological conditions===
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==Overview==
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beta(2)-Microglobulin (beta2-m), a light chain of the major histocompatibility complex class I, forms amyloid fibrils in patients undergoing long-term haemodialysis, causing dialysis-related amyloidosis. Based on a comparison of the X-ray structure obtained at pH 5.7 and that of beta2-m in the histocompatibility complex, it has been proposed that the continuous D-strand observed in the crystal structure at pH 5.7 increases the propensity of beta2-m to self-associate via edge-to-edge interactions, thus initiating the formation of fibrils. To obtain further insight into the mechanism by which amyloid fibrils form, we determined the crystal structure of beta2-m at pH 7.0 at a resolution of up to 1.13 A. The crystal structure at pH 7.0 was basically the same as that at pH 5.6, suggesting that the conversion of the beta-bulge in strand D into a contiguous beta-strand is not unique to the crystals formed under slightly acidic conditions. In other words, although the formation of beta2-m fibrils was enhanced under acidic conditions, it remains unknown if it is related to the increased propensity for the disappearance of the beta-bulge in strand D. We consider that the enhanced fibrillation is more directly coupled with the decreased stability leading to the increased propensity of exposing amyloidogenic regions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17646174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17646174}}
==Disease==
==Disease==
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[[Category: Nakagawa, A.]]
[[Category: Nakagawa, A.]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:38:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:33:29 2008''

Revision as of 22:33, 27 July 2008

Image:2yxf.png

Template:STRUCTURE 2yxf

Contents

The high resolution crystal structure of beta2-microglobulin under physiological conditions

Template:ABSTRACT PUBMED 17646174

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2YXF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of beta2-microglobulin formed at pH 7.0., Iwata K, Matsuura T, Sakurai K, Nakagawa A, Goto Y, J Biochem. 2007 Sep;142(3):413-9. Epub 2007 Jul 23. PMID:17646174

Page seeded by OCA on Mon Jul 28 01:33:29 2008

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