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1aft
From Proteopedia
(New page: 200px<br /><applet load="1aft" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aft" /> '''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE ...) |
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| - | [[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size=" | + | [[Image:1aft.gif|left|200px]]<br /><applet load="1aft" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1aft" /> | caption="1aft" /> | ||
'''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br /> | '''SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of peptide N-AcYTLDADF when bound to the large subunit of | + | The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors. |
==About this Structure== | ==About this Structure== | ||
| - | 1AFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http:// | + | 1AFT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Ribonucleoside-diphosphate reductase]] | [[Category: Ribonucleoside-diphosphate reductase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Barwis, B | + | [[Category: Barwis, B A.]] |
| - | [[Category: Cooperman, B | + | [[Category: Cooperman, B S.]] |
| - | [[Category: Fisher, A | + | [[Category: Fisher, A L.]] |
| - | [[Category: Furst, G | + | [[Category: Furst, G T.]] |
| - | [[Category: Hamann, C | + | [[Category: Hamann, C S.]] |
| - | [[Category: Laub, P | + | [[Category: Laub, P B.]] |
[[Category: ACE]] | [[Category: ACE]] | ||
[[Category: nonstandard type i turn]] | [[Category: nonstandard type i turn]] | ||
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[[Category: transferred noesy]] | [[Category: transferred noesy]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:44:00 2008'' |
Revision as of 09:44, 21 February 2008
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SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES
Overview
The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
About this Structure
1AFT is a Single protein structure of sequence from [1] with as ligand. Active as Ribonucleoside-diphosphate reductase, with EC number 1.17.4.1 Full crystallographic information is available from OCA.
Reference
NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit., Fisher A, Laub PB, Cooperman BS, Nat Struct Biol. 1995 Nov;2(11):951-5. PMID:7583667
Page seeded by OCA on Thu Feb 21 11:44:00 2008
