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2z4h

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[[Image:2z4h.gif|left|200px]]
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{{STRUCTURE_2z4h| PDB=2z4h | SCENE= }}
{{STRUCTURE_2z4h| PDB=2z4h | SCENE= }}
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'''Crystal structure of the Cpx pathway activator NlpE from Escherichia coli'''
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===Crystal structure of the Cpx pathway activator NlpE from Escherichia coli===
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==Overview==
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NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In Escherichia coli, adhesion to abiotic surfaces has been reported to activate the Cpx pathway in an NlpE-dependent manner. External copper ions are also thought to activate the Cpx pathway mediated by NlpE. We determined the crystal structure of NlpE from E. coli at 2.6 A resolution. The structure showed that NlpE consists of two beta barrel domains. The N-terminal domain resembles the bacterial lipocalin Blc, and the C-terminal domain has an oligonucleotide/oligosaccharide-binding (OB) fold. From both biochemical analyses and the crystal structure, it can be deduced that the cysteine residues in the CXXC motif may be chemically active. Furthermore, two monomers in the asymmetric unit form an unusual 3D domain-swapped dimer. These findings indicate that tertiary and/or quaternary structural instability may be responsible for Cpx pathway activation.
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{{ABSTRACT_PUBMED_17698001}}
==About this Structure==
==About this Structure==
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[[Category: Outer memblane lipoprotein]]
[[Category: Outer memblane lipoprotein]]
[[Category: Signaling protein activator]]
[[Category: Signaling protein activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:56:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:39:58 2008''

Revision as of 17:40, 27 July 2008

Image:2z4h.png

Template:STRUCTURE 2z4h

Crystal structure of the Cpx pathway activator NlpE from Escherichia coli

Template:ABSTRACT PUBMED 17698001

About this Structure

2Z4H is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli., Hirano Y, Hossain MM, Takeda K, Tokuda H, Miki K, Structure. 2007 Aug;15(8):963-76. PMID:17698001

Page seeded by OCA on Sun Jul 27 20:39:58 2008

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