2z5o

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[[Image:2z5o.gif|left|200px]]
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{{Seed}}
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[[Image:2z5o.png|left|200px]]
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{{STRUCTURE_2z5o| PDB=2z5o | SCENE= }}
{{STRUCTURE_2z5o| PDB=2z5o | SCENE= }}
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'''Complex of Transportin 1 with JKTBP NLS'''
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===Complex of Transportin 1 with JKTBP NLS===
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==Overview==
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Transportin 1 (Trn1) is a transport receptor that transports substrates from the cytoplasm to the nucleus through nuclear pore complexes by recognizing nuclear localization signals (NLSs). Here we describe four crystal structures of human Trn1 in a substrate-free form as well as in the complex with three NLSs (hnRNP D, JKTBP, and TAP, respectively). Our data have revealed that (1) Trn1 has two sites for binding NLSs, one with high affinity (site A) and one with low affinity (site B), and NLS interaction at site B controls overall binding affinity for Trn1; (2) Trn1 recognizes the NLSs at site A followed by conformational change at site B to interact with the NLSs; and (3) a long flexible loop, characteristic of Trn1, interacts with site B, thereby displacing transport substrate in the nucleus. These studies provide deep understanding of substrate recognition and dissociation by Trn1 in import pathways.
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The line below this paragraph, {{ABSTRACT_PUBMED_17936704}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17936704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17936704}}
==About this Structure==
==About this Structure==
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[[Category: Nucleocytoplasmic]]
[[Category: Nucleocytoplasmic]]
[[Category: Transport protein/rna binding protein complex]]
[[Category: Transport protein/rna binding protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:58:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:44:04 2008''

Revision as of 16:44, 27 July 2008

Image:2z5o.png

Template:STRUCTURE 2z5o

Complex of Transportin 1 with JKTBP NLS

Template:ABSTRACT PUBMED 17936704

About this Structure

2Z5O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for substrate recognition and dissociation by human transportin 1., Imasaki T, Shimizu T, Hashimoto H, Hidaka Y, Kose S, Imamoto N, Yamada M, Sato M, Mol Cell. 2007 Oct 12;28(1):57-67. PMID:17936704

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