2z9l

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{{STRUCTURE_2z9l| PDB=2z9l | SCENE= }}
{{STRUCTURE_2z9l| PDB=2z9l | SCENE= }}
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'''complex structure of SARS-CoV 3C-like protease with JMF1586'''
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===complex structure of SARS-CoV 3C-like protease with JMF1586===
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==Overview==
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Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
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(as it appears on PubMed at http://www.pubmed.gov), where 17981158 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17981158}}
==About this Structure==
==About this Structure==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:04:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:28:49 2008''

Revision as of 10:28, 29 July 2008

Image:2z9l.png

Template:STRUCTURE 2z9l

complex structure of SARS-CoV 3C-like protease with JMF1586

Template:ABSTRACT PUBMED 17981158

About this Structure

2Z9L is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158

Page seeded by OCA on Tue Jul 29 13:28:49 2008

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