2zb5

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{{STRUCTURE_2zb5| PDB=2zb5 | SCENE= }}
{{STRUCTURE_2zb5| PDB=2zb5 | SCENE= }}
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'''Crystal structure of the measles virus hemagglutinin (complex-sugar-type)'''
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===Crystal structure of the measles virus hemagglutinin (complex-sugar-type)===
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==Overview==
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Measles still remains a major cause of childhood morbidity and mortality worldwide. Measles virus (MV) vaccines are highly successful, but the mechanism underlying their efficacy has been unclear. Here we report the crystal structure of the MV attachment protein, hemagglutinin, responsible for MV entry. The receptor-binding head domain exhibits a cubic-shaped beta-propeller structure and forms a homodimer. N-linked sugars appear to mask the broad regions and cause the two molecules forming the dimer to tilt oppositely toward the horizontal plane. Accordingly, residues of the putative receptor-binding site, highly conserved among MV strains, are strategically positioned in the unshielded area of the protein. These conserved residues also serve as epitopes for neutralizing antibodies, ensuring the serological monotype, a basis for effective MV vaccines. Our findings suggest that sugar moieties in the MV hemagglutinin critically modulate virus-receptor interaction as well as antiviral antibody responses, differently from sugars of the HIV gp120, which allow for immune evasion.
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(as it appears on PubMed at http://www.pubmed.gov), where 18003910 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18003910}}
==About this Structure==
==About this Structure==
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[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virion]]
[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:06:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:23:37 2008''

Revision as of 03:23, 29 July 2008

Image:2zb5.png

Template:STRUCTURE 2zb5

Crystal structure of the measles virus hemagglutinin (complex-sugar-type)

Template:ABSTRACT PUBMED 18003910

About this Structure

2ZB5 is a Single protein structure of sequence from Measles virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of measles virus hemagglutinin provides insight into effective vaccines., Hashiguchi T, Kajikawa M, Maita N, Takeda M, Kuroki K, Sasaki K, Kohda D, Yanagi Y, Maenaka K, Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19535-40. Epub 2007 Nov 14. PMID:18003910

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