3b4b

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[[Image:3b4b.gif|left|200px]]
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{{STRUCTURE_3b4b| PDB=3b4b | SCENE= }}
{{STRUCTURE_3b4b| PDB=3b4b | SCENE= }}
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'''T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage'''
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===T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage===
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==Overview==
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The glmS ribozyme is a catalytic riboswitch that is activated for endonucleolytic cleavage by the coenzyme glucosamine-6-phosphate. Using kinetic assays and X-ray crystallography, we identify an active-site mutation of a conserved guanine that abolishes catalysis without perturbing coenzyme binding. Our results provide evidence that coenzyme function requires a specific nucleobase to interact with the nucleophile of the cleavage reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 17990888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17990888}}
==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:22:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:49:55 2008''

Revision as of 17:49, 27 July 2008

Image:3b4b.png

Template:STRUCTURE 3b4b

T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage

Template:ABSTRACT PUBMED 17990888

About this Structure

3B4B is a Protein complex structure of sequences from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.

Reference

Essential role of an active-site guanine in glmS ribozyme catalysis., Klein DJ, Been MD, Ferre-D'Amare AR, J Am Chem Soc. 2007 Dec 5;129(48):14858-9. Epub 2007 Nov 9. PMID:17990888

Page seeded by OCA on Sun Jul 27 20:49:55 2008

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