3b5n

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{{STRUCTURE_3b5n| PDB=3b5n | SCENE= }}
{{STRUCTURE_3b5n| PDB=3b5n | SCENE= }}
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'''Structure of the yeast plasma membrane SNARE complex'''
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===Structure of the yeast plasma membrane SNARE complex===
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==Overview==
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SNARE proteins form a complex that leads to membrane fusion between vesicles, organelles, and plasma membrane in all eukaryotic cells. We report the 1.7A resolution structure of the SNARE complex that mediates exocytosis at the plasma membrane in the yeast Saccharomyces cerevisiae. Similar to its neuronal and endosomal homologues, the S. cerevisiae SNARE complex forms a parallel four-helix bundle in the center of which is an ionic layer. The S. cerevisiae SNARE complex exhibits increased helix bending near the ionic layer, contains water-filled cavities in the complex core, and exhibits reduced thermal stability relative to mammalian SNARE complexes. Mutagenesis experiments suggest that the water-filled cavities contribute to the lower stability of the S. cerevisiae complex.
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{{ABSTRACT_PUBMED_17956869}}
==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:24:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:25:22 2008''

Revision as of 17:25, 28 July 2008

Image:3b5n.png

Template:STRUCTURE 3b5n

Structure of the yeast plasma membrane SNARE complex

Template:ABSTRACT PUBMED 17956869

About this Structure

3B5N is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities., Strop P, Kaiser SE, Vrljic M, Brunger AT, J Biol Chem. 2008 Jan 11;283(2):1113-9. Epub 2007 Oct 22. PMID:17956869

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