3b8p

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[[Image:3b8p.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_3b8p| PDB=3b8p | SCENE= }}
{{STRUCTURE_3b8p| PDB=3b8p | SCENE= }}
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'''Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium'''
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===Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium===
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==Overview==
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The chain length distribution of complex polysaccharides present on the bacterial surface is determined by polysaccharide co-polymerases (PCPs) anchored in the inner membrane. We report crystal structures of the periplasmic domains of three PCPs that impart substantially different chain length distributions to surface polysaccharides. Despite very low sequence similarities, they have a common protomer structure with a long central alpha-helix extending 100 A into the periplasm. The protomers self-assemble into bell-shaped oligomers of variable sizes, with a large internal cavity. Electron microscopy shows that one of the full-length PCPs has a similar organization as that observed in the crystal for its periplasmic domain alone. Functional studies suggest that the top of the PCP oligomers is an important region for determining polysaccharide modal length. These structures provide a detailed view of components of the bacterial polysaccharide assembly machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 18204465 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18204465}}
==About this Structure==
==About this Structure==
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[[Category: Wzz]]
[[Category: Wzz]]
[[Category: Wzzb]]
[[Category: Wzzb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:31:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:14:08 2008''

Revision as of 07:14, 29 July 2008

Image:3b8p.png

Template:STRUCTURE 3b8p

Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium

Template:ABSTRACT PUBMED 18204465

About this Structure

3B8P is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Bacterial polysaccharide co-polymerases share a common framework for control of polymer length., Tocilj A, Munger C, Proteau A, Morona R, Purins L, Ajamian E, Wagner J, Papadopoulos M, Van Den Bosch L, Rubinstein JL, Fethiere J, Matte A, Cygler M, Nat Struct Mol Biol. 2008 Feb;15(2):130-8. Epub 2008 Jan 20. PMID:18204465

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