3bd9

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{{STRUCTURE_3bd9| PDB=3bd9 | SCENE= }}
{{STRUCTURE_3bd9| PDB=3bd9 | SCENE= }}
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'''human 3-O-sulfotransferase isoform 5 with bound PAP'''
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===human 3-O-sulfotransferase isoform 5 with bound PAP===
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==Overview==
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The biosynthesis of heparan sulfate (HS) involves an array of specialized sulfotransferases. Here, we present a study aimed at engineering the substrate specificity of different HS 3-O-sulfotransferase isoforms. Based on the crystal structures, we identified a pair of amino acid residues responsible for selecting the substrates. Mutations of these residues altered the substrate specificities. Our results demonstrate the feasibility of tailoring the specificity of sulfotransferases to modify HS with desired functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 18223645 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18223645}}
==About this Structure==
==About this Structure==
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[[Category: Substrate specificity]]
[[Category: Substrate specificity]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:39:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:31:03 2008''

Revision as of 06:31, 28 July 2008

Image:3bd9.png

Template:STRUCTURE 3bd9

human 3-O-sulfotransferase isoform 5 with bound PAP

Template:ABSTRACT PUBMED 18223645

About this Structure

3BD9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Engineering sulfotransferases to modify heparan sulfate., Xu D, Moon AF, Song D, Pedersen LC, Liu J, Nat Chem Biol. 2008 Mar;4(3):200-2. Epub 2008 Jan 27. PMID:18223645

Page seeded by OCA on Mon Jul 28 09:31:03 2008

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