3beo

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{{STRUCTURE_3beo| PDB=3beo | SCENE= }}
{{STRUCTURE_3beo| PDB=3beo | SCENE= }}
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'''A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases'''
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===A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases===
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==Overview==
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The non-hydrolysing bacterial UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) catalyses the conversion of UDP-GlcNAc into UDP-N-acetylmannosamine, an intermediate in the biosynthesis of several cell-surface polysaccharides. This enzyme is allosterically regulated by its substrate UDP-GlcNAc. The structure of the ternary complex between the Bacillus anthracis UDP-GlcNAc 2-epimerase, its substrate UDP-GlcNAc and the reaction intermediate UDP, showed direct interactions between UDP and its substrate, and between the complex and highly conserved enzyme residues, identifying the allosteric site of the enzyme. The binding of UDP-GlcNAc is associated with conformational changes in the active site of the enzyme. Kinetic data and mutagenesis of the highly conserved UDP-GlcNAc-interacting residues confirm their importance in the substrate binding and catalysis of the enzyme. This constitutes the first example to our knowledge, of an enzymatic allosteric activation by direct interaction between the substrate and the allosteric activator.
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(as it appears on PubMed at http://www.pubmed.gov), where 18188181 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18188181}}
==About this Structure==
==About this Structure==
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[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Udp-glcnac]]
[[Category: Udp-glcnac]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:24:03 2008''

Revision as of 14:24, 28 July 2008

Image:3beo.png

Template:STRUCTURE 3beo

A Structural Basis for the allosteric regulation of non-hydrolyzing UDP-GlcNAc 2-epimerases

Template:ABSTRACT PUBMED 18188181

About this Structure

3BEO is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases., Velloso LM, Bhaskaran SS, Schuch R, Fischetti VA, Stebbins CE, EMBO Rep. 2008 Feb;9(2):199-205. Epub 2008 Jan 11. PMID:18188181

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