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3bi9

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{{STRUCTURE_3bi9| PDB=3bi9 | SCENE= }}
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'''Tim-4'''
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===Tim-4===
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==Overview==
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The T cell immunoglobulin and mucin domain (TIM) proteins are important regulators of T cell responses. Crystal structures of the murine TIM-4 identified a metal-ion-dependent ligand binding site (MILIBS) in the immunoglobulin (Ig) domain of the TIM family. The characteristic CC' loop of the TIM domain and the hydrophobic FG loop shaped a narrow cavity where acidic compounds penetrate and coordinate to a metal ion bound to conserved residues in the TIM proteins. The structure of phosphatidylserine bound to the Ig domain showed that the hydrophilic head penetrates into the MILIBS and coordinates with the metal ion, whereas the aromatic residues on the tip of the FG loop interacted with the fatty acid chains and could insert into the lipid bilayer. Our results also revealed an important role of the MILIBS in the trafficking of TIM-1 to the cell surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 18083575 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18083575}}
==About this Structure==
==About this Structure==
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[[Category: Tim]]
[[Category: Tim]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:36:48 2008''

Revision as of 22:36, 27 July 2008

Image:3bi9.png

Template:STRUCTURE 3bi9

Tim-4

Template:ABSTRACT PUBMED 18083575

About this Structure

3BI9 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds., Santiago C, Ballesteros A, Martinez-Munoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM, Immunity. 2007 Dec;27(6):941-51. PMID:18083575

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