1aoj
From Proteopedia
(New page: 200px<br /><applet load="1aoj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aoj, resolution 2.5Å" /> '''THE SH3 DOMAIN OF EPS...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1aoj.gif|left|200px]]<br /><applet load="1aoj" size=" | + | [[Image:1aoj.gif|left|200px]]<br /><applet load="1aoj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1aoj, resolution 2.5Å" /> | caption="1aoj, resolution 2.5Å" /> | ||
'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''<br /> | '''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''<br /> | ||
==Overview== | ==Overview== | ||
| - | SH3 domains are structurally well-characterized as monomeric modular units | + | SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif. |
==About this Structure== | ==About this Structure== | ||
| - | 1AOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1AOJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Kishan, K | + | [[Category: Kishan, K V.R.]] |
| - | [[Category: Newcomer, M | + | [[Category: Newcomer, M E.]] |
[[Category: eps8]] | [[Category: eps8]] | ||
[[Category: proline rich peptide]] | [[Category: proline rich peptide]] | ||
| Line 20: | Line 20: | ||
[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:39 2008'' |
Revision as of 09:46, 21 February 2008
|
THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER
Overview
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
About this Structure
1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002
Page seeded by OCA on Thu Feb 21 11:46:39 2008
