3bq7

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{{STRUCTURE_3bq7| PDB=3bq7 | SCENE= }}
{{STRUCTURE_3bq7| PDB=3bq7 | SCENE= }}
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'''SAM domain of Diacylglycerol Kinase delta1 (E35G)'''
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===SAM domain of Diacylglycerol Kinase delta1 (E35G)===
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==Overview==
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The diacylglycerol kinase (DGK) enzymes function as regulators of intracellular signaling by altering the levels of the second messengers, diacylglycerol and phosphatidic acid. The DGK delta and eta isozymes possess a common protein-protein interaction module known as a sterile alpha-motif (SAM) domain. In DGK delta, SAM domain self-association inhibits the translocation of DGK delta to the plasma membrane. Here we show that DGK delta SAM forms a polymer and map the polymeric interface by a genetic selection for soluble mutants. A crystal structure reveals that DGKSAM forms helical polymers through a head-to-tail interaction similar to other SAM domain polymers. Disrupting polymerization by polymer interface mutations constitutively localizes DGK delta to the plasma membrane. Thus, polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. Regulation by dynamic polymerization is an emerging theme in signal transduction.
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{{ABSTRACT_PUBMED_18334213}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:00:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:29:05 2008''

Revision as of 11:29, 29 July 2008

Image:3bq7.png

Template:STRUCTURE 3bq7

SAM domain of Diacylglycerol Kinase delta1 (E35G)

Template:ABSTRACT PUBMED 18334213

About this Structure

3BQ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Regulation of Enzyme Localization by Polymerization: Polymer Formation by the SAM Domain of Diacylglycerol Kinase delta1., Harada BT, Knight MJ, Imai S, Qiao F, Ramachander R, Sawaya MR, Gingery M, Sakane F, Bowie JU, Structure. 2008 Mar;16(3):380-7. PMID:18334213

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