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3bta

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[[Image:3bta.gif|left|200px]]
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{{STRUCTURE_3bta| PDB=3bta | SCENE= }}
{{STRUCTURE_3bta| PDB=3bta | SCENE= }}
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'''CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A'''
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===CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A===
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==Overview==
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Botulinum neurotoxin type A (BoNT/A) is the potent disease agent in botulism, a potential biological weapon and an effective therapeutic drug for involuntary muscle disorders. The crystal structure of the entire 1,285 amino acid di-chain neurotoxin was determined at 3.3 A resolution. The structure reveals that the translocation domain contains a central pair of alpha-helices 105 A long and a approximately 50 residue loop or belt that wraps around the catalytic domain. This belt partially occludes a large channel leading to a buried, negative active site--a feature that calls for radically different inhibitor design strategies from those currently used. The fold of the translocation domain suggests a mechanism of pore formation different from other toxins. Lastly, the toxin appears as a hybrid of varied structural motifs and suggests a modular assembly of functional subunits to yield pathogenesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 9783750 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783750}}
==About this Structure==
==About this Structure==
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[[Category: Translocation]]
[[Category: Translocation]]
[[Category: Zinc protease]]
[[Category: Zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:04:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:01:02 2008''

Revision as of 16:01, 28 July 2008

Image:3bta.png

Template:STRUCTURE 3bta

CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A

Template:ABSTRACT PUBMED 9783750

About this Structure

3BTA is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Crystal structure of botulinum neurotoxin type A and implications for toxicity., Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC, Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:9783750

Page seeded by OCA on Mon Jul 28 19:01:02 2008

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