3buy

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[[Image:3buy.jpg|left|200px]]
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{{Seed}}
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[[Image:3buy.png|left|200px]]
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{{STRUCTURE_3buy| PDB=3buy | SCENE= }}
{{STRUCTURE_3buy| PDB=3buy | SCENE= }}
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'''MHC-I in complex with peptide'''
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===MHC-I in complex with peptide===
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==Overview==
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TCR repertoire diversity has been convincingly shown to facilitate responsiveness of CD8+ T cell populations to mutant virus peptides, thereby safeguarding against viral escape. However, the impact of repertoire diversity on the functionality of the CD8+ T cell response to cognate peptide-MHC class I complex (pMHC) recognition remains unclear. Here, we have compared TCRbeta chain repertoires of three influenza A epitope-specific CD8+ T cell responses in C57BL/6 (B6) mice: D(b)NP(366-374), D(b)PA(224-233), and a recently described epitope derived from the +1 reading frame of the influenza viral polymerase B subunit (residues 62-70) (D(b)PB1-F2(62)). Corresponding to the relative antigenicity of the respective pMHCs, and irrespective of the location of prominent residues, the D(b)PA(224)- and D(b)PB1-F2(62)-specific repertoires were similarly diverse, whereas the D(b)NP(366) population was substantially narrower. Importantly, parallel analysis of response magnitude, cytotoxicity, TCR avidity, and cytokine production for the three epitope-specific responses revealed no obvious functional advantage conferred by increased T cell repertoire diversity. Thus, whereas a diverse repertoire may be important for recognition of epitope variants, its effect on the response to cognate pMHC recognition appears minimal.
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(as it appears on PubMed at http://www.pubmed.gov), where 18238896 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18238896}}
==About this Structure==
==About this Structure==
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[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:08:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:35:07 2008''

Revision as of 22:35, 27 July 2008

Image:3buy.png

Template:STRUCTURE 3buy

MHC-I in complex with peptide

Template:ABSTRACT PUBMED 18238896

About this Structure

3BUY is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides., La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2034-9. Epub 2008 Jan 31. PMID:18238896

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