3c9s

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{{STRUCTURE_3c9s| PDB=3c9s | SCENE= }}
{{STRUCTURE_3c9s| PDB=3c9s | SCENE= }}
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'''AaThiL complexed with AMPPCP'''
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===AaThiL complexed with AMPPCP===
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==Overview==
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Thiamin monophosphate kinase (ThiL) catalyzes the ATP-dependent phosphorylation of thiamin monophosphate (TMP) to form thiamin pyrophosphate (TPP), the active form of vitamin B 1. ThiL is a member of a small ATP binding superfamily that also includes the purine biosynthetic enzymes, PurM and PurL, NiFe hydrogenase maturation protein, HypE, and selenophosphate synthase, SelD. The latter four enzymes are believed to utilize phosphorylated intermediates during catalysis. To understand the mechanism of ThiL and its relationship to the other superfamily members, we determined the structure of Aquifex aeolicus ThiL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the products of the reaction, ADP and TPP. The results suggest that AaThiL utilizes a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. The structure of ThiL is compared to those of PurM, PurL, and HypE, and the ATP binding site is compared to that of PurL, for which nucleotide complexes are available.
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(as it appears on PubMed at http://www.pubmed.gov), where 18311927 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18311927}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:30:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:31:38 2008''

Revision as of 18:31, 27 July 2008

Image:3c9s.png

Template:STRUCTURE 3c9s

AaThiL complexed with AMPPCP

Template:ABSTRACT PUBMED 18311927

About this Structure

3C9S is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural studies of thiamin monophosphate kinase in complex with substrates and products(,)., McCulloch KM, Kinsland C, Begley TP, Ealick SE, Biochemistry. 2008 Mar 25;47(12):3810-21. Epub 2008 Mar 1. PMID:18311927

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