3cbs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3cbs.gif|left|200px]]
+
{{Seed}}
 +
[[Image:3cbs.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3cbs| PDB=3cbs | SCENE= }}
{{STRUCTURE_3cbs| PDB=3cbs | SCENE= }}
-
'''CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310)'''
+
===CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310)===
-
==Overview==
+
<!--
-
Retinoids play important roles in diverse cellular processes including growth, cell differentiation and vision. Many natural and synthetic retinoids are used as drugs in dermatology and oncology. A large amount of data has been accumulated on the cellular activity of different synthetic retinoids. They are stabilized and transported inside the cell cytoplasm by binding and transport proteins, such as cellular retinol-binding proteins and cellular retinoic acid binding proteins (CRABPs). The structures of human CRABP II in complex with two different synthetic retinoids, Ro13-6307 and Ro12--7310 (at 2.1 and 2.0 A resolution, respectively) and of bovine CRABP I in complex with a retinobenzoic acid, Am80 (at 2.8 A resolution) are described. The binding affinities of human CRABP I and II for the retinoids studied here have been determined. All these compounds have comparable binding affinities (nanomolar range) for both CRABPs. Apart from the particular interactions of the carboxylate group of the retinoids with specific protein groups, each structure reveals characteristic interactions. Studying the atomic details of the interaction of retinoids with retinoid-binding proteins facilitates the understanding of the kinetics of retinoid trafficking inside the cytoplasm.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10531482}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10531482 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10531482}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Kleywegt, G J.]]
[[Category: Kleywegt, G J.]]
[[Category: Retinoic-acid transport]]
[[Category: Retinoic-acid transport]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:32:47 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:56:05 2008''

Revision as of 21:56, 28 July 2008

Image:3cbs.png

Template:STRUCTURE 3cbs

CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310)

Template:ABSTRACT PUBMED 10531482

About this Structure

3CBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids., Chaudhuri BN, Kleywegt GJ, Broutin-L'Hermite I, Bergfors T, Senn H, Le Motte P, Partouche O, Jones TA, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1850-7. PMID:10531482

Page seeded by OCA on Tue Jul 29 00:56:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cbs"
Personal tools