3crd

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{{STRUCTURE_3crd| PDB=3crd | SCENE= }}
{{STRUCTURE_3crd| PDB=3crd | SCENE= }}
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'''NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES'''
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===NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES===
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==Overview==
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Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs (caspase recruitment domains) of adaptor proteins and prodomains of caspases. We have solved the CARD structure of the RAIDD adaptor protein that recruits ICH-1/caspase-2. It consists of six tightly packed helices arranged in a topology homologous to the Fas death domain. The surface contains a basic and an acidic patch on opposite sides. This polarity is conserved in the ICH-1 CARD as indicated by homology modeling. Mutagenesis data suggest that these patches mediate CARD/CARD interaction between RAIDD and ICH-1. Subsequent modeling of the CARDs of Apaf-1 and caspase-9, as well as Ced-4 and Ced-3, showed that the basic/acidic surface polarity is highly conserved, suggesting a general mode for CARD/CARD interaction.
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{{ABSTRACT_PUBMED_9695946}}
==About this Structure==
==About this Structure==
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3CRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRD OCA].
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3CRD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRD OCA].
==Reference==
==Reference==
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[[Category: Caspase recruitment domain]]
[[Category: Caspase recruitment domain]]
[[Category: Homophilic interaction]]
[[Category: Homophilic interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:57:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:45:01 2008''

Revision as of 09:45, 27 July 2008

Image:3crd.png

Template:STRUCTURE 3crd

NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES

Template:ABSTRACT PUBMED 9695946

About this Structure

3CRD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment., Chou JJ, Matsuo H, Duan H, Wagner G, Cell. 1998 Jul 24;94(2):171-80. PMID:9695946

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